(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate
2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate
CAS: 1181083-81-7
Molecular Formula: C19H21FN4O3S
(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate - Names and Identifiers
(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate - Physico-chemical Properties
| Molecular Formula | C19H21FN4O3S |
| Molar Mass | 404.46 |
| Density | 1.47±0.1 g/cm3(Predicted) |
| Boling Point | 553.7±60.0 °C(Predicted) |
| Solubility | DMSO : 62.5 mg/mL (154.53 mM; Need ultrasonic) |
| pKa | 1.29±0.20(Predicted) |
| Storage Condition | 2-8°C(protect from light) |
(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.472 ml | 12.362 ml | 24.724 ml |
| 5 mM | 0.494 ml | 2.472 ml | 4.945 ml |
| 10 mM | 0.247 ml | 1.236 ml | 2.472 ml |
| 5 mM | 0.049 ml | 0.247 ml | 0.494 ml |
Last Update：2024-01-02 23:10:35
(Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate - Reference Information
| biological activity | CLP290 is an oral activator of the neuro-specific K -Cl − cotransporter KCC2, it has the potential to study a variety of neurological and psychiatric disorders. CLP290 can significantly reduce the level of AVP and blood glucose in the blood of STZ rats. |
| Target | KCC2 |
| Animal Model: | Adult male rats (300 g, >postnatal day 60) |
| Dosage: | 100 mg/kg |
| Administration: | Oral gavage; 100 mg/kg; twice a day; 7day |
| Result: | Rescued established MIH and prevented its development by restoring Cl - transport or preventing its deficiency in the SDH. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: 2{[(5Z)2(1,2diazinan1yl)4oxo4,5dihydro1,3thiazol5ylidene]Methyl}5fluorophenyl pyrrolidine1carboxylate Visit Supplier Webpage Request for quotationCAS: 1181083-81-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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